Sick and Tired followed Left Outside Alone as the second single from Anastacia in 2004, and became the album's second large European hit, reaching the top five in several countries. The record was her first after treatment for breast cancer in 2003, and its songs were written in that period. The track keeps the formula that carried the album: a compact verse, a chorus opened out for the full band, and a vocal line placed deliberately at the edge of the singer's chest register. It has remained in her live sets in both band and orchestral versions.